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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTNNB1
All Species:
45.15
Human Site:
S374
Identified Species:
76.41
UniProt:
P35222
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35222
NP_001091679.1
781
85497
S374
G
L
H
L
T
D
P
S
Q
R
L
V
Q
N
C
Chimpanzee
Pan troglodytes
XP_001137676
774
84747
S367
G
L
H
L
T
D
P
S
Q
R
L
V
Q
N
C
Rhesus Macaque
Macaca mulatta
XP_001115474
511
55731
E175
V
C
Q
V
G
G
I
E
A
L
V
R
T
V
L
Dog
Lupus familis
XP_850439
744
81740
S364
G
K
H
L
T
S
N
S
P
R
L
V
Q
N
C
Cat
Felis silvestris
Mouse
Mus musculus
Q02248
781
85452
S374
G
L
H
L
T
D
P
S
Q
R
L
V
Q
N
C
Rat
Rattus norvegicus
Q9WU82
781
85436
S374
G
P
H
L
T
D
P
S
Q
R
L
V
Q
N
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516985
781
85506
S374
G
L
H
L
T
D
P
S
Q
R
L
V
Q
N
C
Chicken
Gallus gallus
NP_990412
781
85420
S374
G
L
H
L
T
D
P
S
Q
R
L
V
Q
N
C
Frog
Xenopus laevis
P26233
781
85431
S374
G
L
H
L
T
D
S
S
Q
R
L
V
Q
N
C
Zebra Danio
Brachydanio rerio
NP_571134
780
85502
S373
G
L
H
L
T
D
P
S
Q
R
L
V
Q
N
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18824
843
91134
S382
A
M
H
L
G
N
M
S
P
R
L
V
Q
N
C
Honey Bee
Apis mellifera
XP_391947
811
88602
S383
A
M
H
L
G
N
P
S
Q
R
L
V
Q
N
C
Nematode Worm
Caenorhab. elegans
O44326
678
74493
A342
L
L
E
I
I
R
V
A
N
D
G
M
T
A
C
Sea Urchin
Strong. purpuratus
NP_001027543
825
89711
S395
G
L
H
L
G
H
Q
S
N
R
L
V
Q
N
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
65.4
66.4
N.A.
99.8
99.7
N.A.
99.7
99.3
97.4
97.1
N.A.
65.7
67.6
28.5
67.2
Protein Similarity:
100
99
65.4
77.4
N.A.
99.8
99.7
N.A.
99.8
99.6
99
98.9
N.A.
77.2
80.1
46.4
77.7
P-Site Identity:
100
100
0
73.3
N.A.
100
93.3
N.A.
100
100
93.3
100
N.A.
60
73.3
13.3
73.3
P-Site Similarity:
100
100
13.3
73.3
N.A.
100
93.3
N.A.
100
100
93.3
100
N.A.
73.3
86.6
33.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
0
0
0
0
8
8
0
0
0
0
8
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
93
% C
% Asp:
0
0
0
0
0
58
0
0
0
8
0
0
0
0
0
% D
% Glu:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
72
0
0
0
29
8
0
0
0
0
8
0
0
0
0
% G
% His:
0
0
86
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
8
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
8
65
0
86
0
0
0
0
0
8
86
0
0
0
8
% L
% Met:
0
15
0
0
0
0
8
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
0
15
8
0
15
0
0
0
0
86
0
% N
% Pro:
0
8
0
0
0
0
58
0
15
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
8
0
65
0
0
0
86
0
0
% Q
% Arg:
0
0
0
0
0
8
0
0
0
86
0
8
0
0
0
% R
% Ser:
0
0
0
0
0
8
8
86
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
65
0
0
0
0
0
0
0
15
0
0
% T
% Val:
8
0
0
8
0
0
8
0
0
0
8
86
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _